Aptamers were discovered at the University of Colorado by Dr. Larry Gold, SomaLogic's founder, chairman and CSO. The company's team includes many of the pioneers in the aptamer field, and SomaLogic has developed an extraordinarily strong portfolio of intellectual property around aptamers and their in vitro diagnostic and research applications.

SomaLogic has licensed from Gilead Sciences, Inc. the worldwide exclusive rights to the entire aptamer patent estate for in vitro diagnostics (Gilead obtained the technology in its 1999 acquisition of Boulder, Colorado-based NeXstar, Inc.). In addition, SomaLogic owns critical U.S. patents and applications, and the company continues its research to broaden the applications of aptamers and establish them as the preferred technology for proteomics. Patent applications have been filed throughout the world, providing the basis for the development of a truly global business.

In addition to the select patents below, you can review the full list of more than 160 issued U.S. patents. You can read the actual patents at the U.S. Patent & Trademark Office.

Title	United States Patent Number	Issue Date
Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands	6,482,594	11/19/02
Nucleic acid ligand diagnostic biochip	6,458,543	10/01/02
Photoselection of nucleic acid ligands	6,458,539	10/01/02
Modified SELEX processes without purified protein	6,376,190	04/23/02
Methods of producing nucleic acid ligands	6,344,318	02/05/02
Nucleic Acid Ligand Diagnostic Biochip	6,242,246	06/05/01
High Affinity Nucleic Acid Ligands Containing Modified Nucleotides	6,184,364	02/06/01
Systematic Evolution of Ligands by Exponential Enrichment: Photoselection of Nucleic Acid Ligands and Solution SELEX	6,001,577	12/14/99
High Affinity Nucleic Acid Ligands Containing Modified Nucleotides	5,958,691	09/28/99
Method for Detecting a Target Compound in a Substance using a Nucleic Acid Ligand	5,874,218	02/23/99
Use of Nucleic Acid Ligands in Flow Cytometry	5,853,984	12/29/98
Method and Apparatus for Determining Consensus Secondary Structures for Nucleic Acid Sequences	5,843,732	12/01/98
Method for Detecting a Target Molecule in a Sample Using a Nucleic Acid Ligand	5,843,653	12/01/98
Method of Producing Nucleic Acid Ligands	5,817,785	10/6/98
Enzyme Linked Oligonucleotide Assays (ELONAS)	5,789,163	08/04/98
Systematic Evolution of Ligands by Exponential Enrichment: Photoselection of Nucleic Acid Ligands and Solution Selex	5,763,177	06/9/98
Nucleic Acid Ligands (SELEX)	5,696,249	12/09/97
High Affinity Nucleic Acid Ligands Containing Modified Nucleotides	5,660,985	08/26/97
Method of Producing Nucleic Acid Ligands	5,595,877	01/21/97
Solution SELEX	5,567,588	10/22/96
Nucleic Acid Ligands	5,270,163	12/14/93