Scientific Publications

SomaLogic is committed to rapid publication of our scientific findings in peer-reviewed literature. Below are selected articles by SomaLogic scientists and their collaborators. A more complete list of publications from users of our proteomics technology as well as SomaLogic scientists can be downloaded here.

Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease (2016) PJ Ganz, B Heidecker, K Hveem, C Jonasson, S Kato MR Segal, DG Sterling, and SA Williams. Journal of the American Medical Association 315:2532-2541. PUBMED link (SUBSCRIPTION REQUIRED). For access to electronic version, please contact us.
Also see accompanying editorial: M Sabatine (2016) Using Aptamer-Based Technology to Probe the Plasma Proteome for Cardiovascular Disease Prediction. JAMA 315:2525-2526. (SUBSCRIPTION REQUIRED).

Embracing proteins: structural themes in aptamer-protein complexes (2016) AD Gelinas, DR Davies, and N Janjic. Current Opinion in Structural Biology 36:122-32.

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy (2013) FS Loffredo, ML Steinhauser, SM Jay, J Gannon, JR Pancoast, P Yalamanchi, M Sinha, C Dall’Osso, D Khong, JL Shadrach, CM Miller, BS Singer, A Stewart, N Psychogios, RE Gerszten, AJ Hartigan, M-J Kim, T Serwold, AJ Wagers, and RT Lee.
Cell 153:829-839.

Measurement of Cetuximab and Panitumumab-Unbound Serum EGFR Extracellular Domain Using an Assay Based on Slow Off-Rate Modified Aptamer (SOMAmer) Reagents (2013) NJ Park, X Wang, A Diaz, DM Goos-Root, C Bock, JD Vaught, W Sun and CM Strom. PLOS ONE (2013) 8(4):e61002.

Early Detection of Malignant Pleural Mesothelioma in Asbestos-Exposed Individuals with a Noninvasive Proteomics-Based Surveillance Tool (2012) RM Ostroff, MR Mehan, A Stewart, D Ayers, EN Brody, SA Williams, S Levin, B Black, M Harbut, M Carbone, C Goparaji C, and HI Pass.
PLOS ONE 7(10): e46091

Life’s Simple Measures: Unlocking the Proteome (2012) E Brody, L Gold, R Ostroff, J Rohloff, J Walker, and D Zichi. Journal of Molecular Biology 422: 595-606. (2012). SUBSCRIPTION REQUIRED

High-content affinity-based proteomics: unlocking protein biomarker discovery (2010) EN Brody, L Gold, RM Lawn, JJ Walker, and D Zichi.
Expert Review of Molecular Diagnostics 10(8):1013-1022

Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides (2015) SK Wolk, RK Shoemaker, WS Mayfield, AL Mestdagh, and N Janjic. Nucleic Acids Res. 2015 Oct 4. pii: gkv981.

Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts (2015) KA Olson, AL Beatty, B Heidecker, MC Regan, EN Broady, T Foremen, S Kato, RE Mehler, BS Singer, K Hveem, H Dalen, DG Sterling, RM Lawn, NB Schiller, SA Williams, MA Whooley, and P Ganz. European Heart Journal, online ahead of print August 20, 2015. SUBSCRIPTION REQUIRED

Practical synthesis of cytidine-5-carboxamide-modified nucleotide reagents (2015) JC Rohloff, C Fowler, B Ream, JD Carter, G Wardle and T Fitzwater. Nucleoside, Nucleotides and Nucleic Acids 34:180-198.

Fit for the Eye: Aptamers in Ocular Disorders (2016) DW Drolet, LS Green, L Gold, and N Janjic. Nucleic Acid Ther. 2016 Jan 12. 

Elucidating Novel Serum Biomarkers Associated with Pulmonary Tuberculosis Treatment (2013) MA De Groote, P Nahid, L Jarlsberg, JL Johnson, M Weiner, G Muzanyi, N Janjic, DG Sterling, and UA Ochsner. PLOS ONE 8(4): e61002. doi:10.1371/journal.pone.0061002

Slow Off-Rate Modified Aptamer Arrays for Biomarker Discovery and Diagnostic Applications (2012) JJ Walker, EN Brody and L Gold.
In “Microarrays in Diagnostics and Biomarker Development.” (Ed: B Jordan) Springer, ISBN 978-3-642-28202-7.

Protein Signature of Lung Cancer Tissues (2012) MR Mehan, D Ayers, D Thirstup, W Xiong, RM Ostroff, EN Brody, JJ Walker, L Gold, TC Jarvis, N Janjic, GS Baird, and SK Wilcox.
PLoS ONE 7(4): e35157.

Age-Dependent Changes in the Cerebrospinal Fluid Proteome by SOMAmer Array (2012) G Baird, S Nelson, T Keeney, A Stewart, S Williams, E Peskind, and T Montine. American Journal of Pathology. 180(2):446-56.

Aptamers as Therapeutic and Diagnostic Agents (2000) EN Brody and L Gold. Rev. Mol. Biotech. 74: 5-13. SUBSCRIPTION REQUIRED

High Affinity Ligands from In Vitro Selection. (1998) K Morris, KB Jensen, M Julin, M Weil and L Gold. PNAS 95(6): 2902-2907.

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Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts (2015) KA Olson, AL Beatty, B Heidecker, MC Regan, EN Broady, T Foremen, S Kato, RE Mehler, BS Singer, K Hveem, H Dalen, DG Sterling, RM Lawn, NB Schiller, SA Williams, MA Whooley, and P Ganz. European Heart Journal, online ahead of print August 20, 2015. SUBSCRIPTION REQUIRED

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy (2015) Y Hathout, E Brody, PR Clemens, L Cripe, RK DeLisle, P Furlong, H Gordish-Dressman, L Hache, E Henricson, EP Hoffman, YM Kobayashi, A Lorts, JK Mah, C McDonald, B Mehler, S Nelson, M Nikrad, B Singer, F Steele, D Sterling, HL Sweeney, S Williams, and L Gold.
Proceedings of the National Academy of Sciences USA 112(23):7153-8

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents (2014) JC Rohloff, AD Gelinas, TC Jarvis, UA Ochsner, DJ Schneider, L Gold and N Janjic. Molecular Therapy Nucleic Acids 3:e201; doi:10.1038/mtna.2014.49

Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components (2014) A Baumstummler, D Lehmann, N Janjic and UA Ochsner. Lett Appl Microbiol 59:422-431

Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis (2014) P Nahid, E Bliven-Sizemore, LG Jarlsberg, MA De Groote, JL Johnson, G Muzanyi, M Engle, M Weiner, N Janjic, DG Sterling and UA Ochsner. Tuberculosis 94:187-196. SUBSCRIPTION REQUIRED

From SOMAmer-based biomarker discovery to diagnostic and clinical applications: A SOMAmer-based, streamlined multiplex proteomic assay (2011) S Kraemer, JD Vaught, C Bock, L Gold, E Katilius, TR Keeney, N Kim, NA Saccamano, SK Wilcox, D Zichi, and GM Sanders.
PLoS ONE 6(10): e26332. doi:10.1371/journal.pone.0026332

Making the cut: Untangling clinical protein biomarker discovery and validation (2011) L Gold, S Williams, N Janjic, N Saccomano, and F Steele. Biomarkers in Medicine 5(2):189-191.

Proteomics and Diagnostics: Let’s Get Specific, Again (2008) D Zichi, B Eaton, B Singer, and L Gold.
Current Opinion in Chemical Biology 12:78–85. SUBSCRIPTION REQUIRED

Let’s get specific: The relationship between specificity and affinity. (1995) BE Eaton, L Gold and DA Zichi. Chem. Biol. 2(10): 633-638.

Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor (2015) TC Jarvis, DR Davies. A Hisaminato, DI Resnicow, S Gupta, SM Waugh, A Nagabukuro, T Wadatsu, H Hishigaki, B Gawande, C Zhang, SK Wolk, WS Mayfield, Y Nakaishi, AB Burgin, LJ Stewart, TE Edwards, AD Gelinas, DJ Schneider and N Janjic. Structure 23(7):1293-1304. SUBSCRIPTION REQUIRED

Circulating Proteomic Signatures of Chronological Age (2014) C Menni, SJ Kiddle, M Mangino, A Vinũela, M Psatha, C Steves, M Sattlecker, A Buil, S Newhouse, S Nelson, S Williams, N Voyle, H Soininen, I Kloszewska, P Mecocci, M Tsolaki, B Vellas, S Lovestone, TD Spector, R Dobson and AM Valdes. Journal of Gerontology: Biological Sciences 70(7):809-16.

Validation of a blood protein signature for non-small cell lung cancer (2014) M Mehan, SA Williams, JM Siegfried, WL Bigbee, JL Weissfeld, DO Wilson, HI Pass, WN Rom, T Muley, M Meister, W Franklin, YE Miller, EN Brody, and RM Ostroff.
Clinical Proteomics 11:32

Alzheimer’s disease biomarker discovery using SOMAscan multiplexed protein technology (2014) M Sattlecker, SJ Kiddle, S Newhouse, P Proitsi, S Nelson, S Williams, C Johnston, R Killick, A Simmons, E Westman, A Hodges, H Soininen, I Kloszewska, P Mecocci, M Tsolaki, B Vellas, S Lovestone, on behalf of the AddNeuroMed Consortium and RJB Dobson. Alzheimer’s & Dementia 6:724-734.

Systematic selection of modified aptamer pairs for diagnostic sandwich assays (2014) UA Ochsner, LS Green, L Gold and N Janjic. Biotechniques 56:125-133.

Rapid Histochemistry Using Slow Off-rate Modified Aptamers With Anionic Competition. (2011) S Gupta, D Thirstrup, TC Jarvis, DJ Schneider, SK Wilcox, J Carter, C Zhang, A Gelinas, A Weiss, N Janjic, and GS Baird.
Applied Immunohistochemistry & Molecular Morphology. 19(3):273-8. SUBSCRIPTION REQUIRED

Aptamers and the RNA World, Past and Present (2010) L Gold, N Janjic, T Jarvis, DD Schneider, JJ Walker, SK Wilcox and D Zichi. Cold Spring Harbor Perspectives in Biology, doi:10.1102/cshperspect.a003582 (published in Advance, December 8, 2010).

Aptamers: The New Frontier in Drug Development? (2007) B Carlson. Biotechnology Healthcare. April 2007: 31-36. PDF

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase. (1990) C Tuerk and L Gold. Science 249: 505-510. SUBSCRIPTION REQUIRED

Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform (2014) J Webber, TC Stone, E Katilius, BC Smith, B Gordon, MD Mason, Z Tabi, IA Brewis and A Clayton. Mol Cell Proteomics 13:1050-1064.

DTC-and-Me: Patient, Provider, Proteins and Regulators (2014) F Steele and L Gold. Journal of Personalized Medicine 4:79-87.

Beyond antibodies: new affinity reagents to unlock the proteome (2014) B Lollo, F Steele and L Gold. Proteomics 14:638-644.

Interaction with both ZNRF3 and LGR4 is required for the signaling activity of R-spondin (2013) X Yang, R Zamponi, O Charlat, M Ramones, S Swalley, X Jiang, D Rivera, W Tschatz, B Lu, L Quinn, C Dimitri, J Parker, D Jeffery, SK Wilcox, M Watrobka, P LeMotte, B Granda, JA Porter, VE Myer, A Loew and F Cong. EMBO Reports 14:1120-1126.

Taking measure of personalized medicine: the proteome (2013) F Steele and L Gold. Personalized Medicine 10(2): 177-182. (For reprint contact

Unlocking biomarker discovery: Large scale application of aptamer proteomic technology for early detection of lung cancer (2010) RM Ostroff, WL Bigbee, W Franklin, L Gold, M Mehan, YE Miller, HI Pass, WN Rom, JM Siegfried, A Stewart, JJ Walker, JL Weissfeld, SA Williams, D Zichi, EN Brody.
PLoS ONE 5(12): e15003. doi:10.1371/journal.pone.0015003

Expanding the Chemistry of DNA for in Vitro Selection (2010) JD Vaught, C Bock, J Carter, T Fitzwater, M Otis, D Schneider, J Rolando, S Waugh, SK Wilcox and B Eaton. J Am Chem Soc 132:4141–4151. SUBSCRIPTION REQUIRED

The stability of the circulating human proteome to variations in sample collection and handling procedures measured with an aptamer-based proteomics array. (2010) R Ostroff, T Foreman, TR Keeney, S Stratford, JJ Walker, and D Zichi. Journal of Proteomics 73:649-66. SUBSCRIPTION REQUIRED

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand (2014) AD Gelinas, DR Davies, TE Edwards, JC Rohloff, JD Carter, C Zhang, S Gupta, Y Ishikawa, M Hirota, Y Nakaishi, TC Jarvis and N Janjic.
The Journal of Biological Chemistry 289:8720-8734.

Chemically-Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking its Interaction with Interleukin-6 Receptor (2014) S Gupta, M Hirota, SM Waugh, I Murakami, T Suzuki, M Muraguchi, M Shibamori, Y Ishikawa, TC Jarvis, JD Carter, C Zhang, B Gawande, M Vrkljan, N Janjic and DJ Schneider. The Journal of Biological Chemistry 289:8706-19

Candidate blood proteome markers of Alzheimer’s disease onset and progression: a systematic review and replication study (2013) SJ Kiddle, M Sattlecker, P Proitsi, A Simmons, E Westman, C Bazenet, SK Nelson, S Williams, A Hodges, C Johnston, H Soininen, I Kloszewska, P Mecocci, M Tsolaki, B Vellas, S Newhouse, S Lovestone and RJ Dobson.
J Alzheimers Disease 38:515-531.

Detection of Clostridium difficile toxins A, B, and binary toxin with slow off-rate modified aptamers (2013) UA Ochsner, E Katilius and N Janjic.
Diagnostic Microbiology and Infectious Disease 76:278-285. SUBSCRIPTION REQUIRED

Unique Motifs and Hydrophobic Interactions Shape the Binding of Modified DNA Ligands to Protein Targets (2012) DR Davies, AD Gelinas, C Zhang, JC Rohloff, JD Carter, D O’Connell, SM Waugh, SK Wolk, WS Mayfield, AB Burgin, TE Edwards, LJ Stewart, L Gold, N Janjic and TC Jarvis. Proc. Natl. Acad. Sci. USA 109: 19971-19976.

Aptamer-based multiplexed proteomic technology for biomarker discovery (2010) L Gold, D Ayers, J Bertino, A Bock, C Bock, EN Brody, J Carter, J Cheronis, A Dalby, B Eaton, T Fitzwater, D Flather, A Forbes, T Foreman, C Fowler, B Gawande, M Goss, M Gunn, S Gupta, D Halladay, J Heil, J Heilig, B Hicke, G Husar, N Janjic, T Jarvis, S Jennings, E Katilius, T Keeney, N Kim, T Koch, S Kraemer, L Kroiss, N Le, W Lindsey, B Lollo, W Mayfield, M Mehan, R Mehler, M Nelson, S Nelson, D Nieuwlandt, M Nikrad, U Ochsner, R Ostroff, M Otis, S Pietrasiewicz, D Resnicow, J Rohloff, G Sanders, S Sattin, D. Schneider, B Singer, M Stanton, A Sterkel, A Stewart, S Stratford, T Vandenbroeke, J Vaught, M Vrkljan, J Walker, M Watrobka, S Waugh, A Weiss, S Wilcox, A Wolfson, S Wolk, C Zhang, and D Zichi. PLoS ONE 5(12): e15004. doi:10.1371/journal.pone.0015004