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Science
Article published May 6, 2005
written by Peter Gwynne and Gary Heebner
Interview
with Larry Gold and Todd Gander
Frost & Sullivan Movers & Shakers Series
article published November, 2004
Read the Transcript of the Interview
The New York Times
article published January 21, 2003
written by Andrew Pollack
RNA is not only a tape, but a shape.
Most scientists view RNA as a tape, a string of letters of the genetic
code. The important thing is the information it holds.
But it turns out that RNA can also fold into three-dimensional shapes
that can bind to something like a protein by shape, as a key fits in
a lock.
A Perspective on Protein Microarrays
Nature Biotechnology
article published March 1, 2002
written by Peter Mitchell
Proteins, not genes, are the true targets of medicines, but their analysis by array technology still poses significant challenges for drug developers.
Read the complete article
(subscription or pay per view)
Nature
article published January 10, 2002
written by Alison Abbott
At the proteomics frontier, dozens of companies are trying to develop the protein equivalent of DNA microarrays. But designing these chips poses much tougher technical challenges, says Alison Abbott.
PROTEOMICS: Searching for Recipes for Protein Chips
Science
article published December 7, 2001
written by Robert F. Service
When medical visionaries talk about the future, many offer
up the image of a computer chip or CD-ROM that stores your complete DNA
sequence. Interested in your odds of getting Huntington's disease or breast
cancer? Just have your doctor scan your DNA.
In most cases, however, we want to know what we've got right now, not
what we might face in 30 years. DNA and genes won't always provide immediate
answers, but looking at proteins just might. That's because proteins reflect
the chemistry taking place inside cells, chemistry that is altered in
potentially diagnostic ways by different diseases. The problem is that
such diagnoses depend on technology that does not exist today: chips that
can spot hundreds or thousands of distinct proteins at a time from a sample,
say, of blood or urine.
Read
the complete article
(subscription or pay per view)
Boulder Daily Camera
article published October 6, 2001
written by Cherie Strain
Boulder-based SomaLogic has positioned itself for growth in an emerging
pharmaceutical field. It is developing a diagnostic chip designed to
identify disease before patients show symptoms. SomaLogic's market is
proteomics. Born of the genomics industry, proteomics is the study of
protein levels, rather than genes, to observe health and sickness.
GenomeWeb
article published March, 2001
written by John S. Macneil
With scores of businesses looking to develop protein chips, it would seem a company with years of experience mass-producing microarrays might have a leg up on the competition.
But Affymetrix, maker of the widely used GeneChip DNA microarrays, has no immediate plans to invest in protein chip research. “It’s just too far in the future,” a spokeswoman said....In fact, there are a number of early versions of a protein chip already on the market.
Aptamers: New Way To Probe Proteins?
article published January/February, 2001
written by Dr. Ricki A. Lewis
Although each cell in the body has the same genetic blueprint, the genes that are used to manufacture proteins sculpt the characteristics of cells in space and time. Different patterns of gene expression distinguish a bone cell from a nerve cell, a cancerous cell from one with normal controls on division and even determine how the same cell changes as a person ages or encounters environmental stimuli.
