SOMAmer® reagents: A new class of protein-affinity molecules

At the heart of SomaLogic's proteomic platform are SOMAmer (Slow Off-rate Modified Aptamer) protein-binding reagents, each of which combine the best properties of antibodies (range of target proteins) and traditional aptamers (durability and reliability), and each of which is highly specific for its respective cognate protein.

A SOMAmer reagent consists of a unique short DNA sequence that incorporates several bases that have been modified to include "protein-like" side chains, and a 5'-linker optimized for use in the SOMAscan assay. To date, we've developed SOMAmer reagents to a broad array of more than 1,300 different protein targets critical to normal and disease biology, and we continue to expand our SOMAmer reagent library at regular intervals.
SomaLogic now offers many of its SOMAmer reagents individually for research users. In addition, we can make custom SOMAmers to your protein of interest (and "fit-for-purpose" for the assay you intend to use the reagent in) through our SOMAmer Discovery Service.

Figure: The crystal structure of a SOMAmer-protein pair reveals the unique binding properties of SOMAmer reagents compared to antbodies or traditional aptamers (base modifications are in purple). This new generation of powerful protein-binding reagents are at the core of our SOMAscan assay, the biomarker discovery engine that drives our efforts.